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The low-density lipoprotein receptor gene family codes for a class of structurally related cell surface receptors that fulfill diverse biological functions in different organs, tissues, and cell types. The role that is most commonly associated with this evolutionarily ancient family is cholesterol homeostasis (maintenance of appropriate concentration of cholesterol). In humans, excess cholesterol in the blood is captured by low-density lipoprotein (LDL) and removed by the liver via endocytosis of the LDL receptor. Recent evidence indicates that the members of the LDL receptor gene family are active in the cell signalling pathways between specialized cells in many, if not all, multicellular organisms. There are seven members of the LDLR family in mammals, namely: * LDLR * VLDL receptor (VLDLR) * ApoER2, or LRP8 * Low density lipoprotein receptor-related protein 4 * * also known as multiple epidermal growth factor (EGF) repeat-containing protein (MEGF7) * LDLR-related protein 1 * LDLR-related protein 1b * Megalin. ==Human proteins containing this domain == Listed below are human proteins containing low-density lipoprotein receptor domains: 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Low-density lipoprotein receptor gene family」の詳細全文を読む スポンサード リンク
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